Figure1 (IMAGE)

Tokyo Medical and Dental University

Figure1

Caption

Study design to create a database of transcripts, called TRAILS (TRAnscriptomic resource of Immune cells using Long-read Sequencing), from different human immune cell subsets and downstream analysis. First, long-read sequencing is performed on immune cell populations to generate full-length isoform sequences. Key attributes of the TRAILS include novelty, repetitive element insertion, cell-type specific expression patterns, translational efficiency, and coding potential. In addition, publicly available short-read RNA sequencing datasets are remapped to the TRAILS to identify disease-linked isoforms through isoform switch analysis, quantitative trait loci (QTL) analysis, and colocalization analysis. 

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Department of Genomic Function and Diversity, TMDU

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