Research summary (IMAGE) Toho University Caption (Top left) Research aim. (Top right) Schema of mitochondrial respiratory chain supercomplex localization and function. (Bottom left) Analysis of supercomplex formation by hrCN-PAGE and in-gel activity assay. (Bottom right) Conclusion: “Large” supercomplex formation decrease correlated with the progression of neurodegenerative diseases. Credit Ayako Okado-Matsumoto Usage Restrictions None License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.