Study explores the role of Ctdnep1 in RANKL-induced osteoclast differentiation (IMAGE)
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During osteoclast differentiation, Ctdnep1 expression remains consistent, yet its depletion results in heightened osteoclast formation and activity. Mechanistically, Ctdnep1 demonstrates a suppressive effect on the RANKL signaling pathway, suggesting its role as a negative regulator in osteoclast differentiation.
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Professor Tadayoshi Hayata from Tokyo University of Science
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