New target for inflammation regulation discovered (IMAGE)

University of California - Santa Cruz

New target for inflammation regulation discovered

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UC Santa Cruz researchers have discovered that LOUP is a multifunctional gene in immune cells called monocytes. LOUP can work inside the nucleus to control its neighbor SPI1. They also discovered that LOUP RNA can leave the nucleus and produce a small peptide in the cytoplasm leading to an increase in the protein SPI1 and causing downregulation of NF-kB, the master controller of inflammation.

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Carpenter Lab, UC Santa Cruz

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