Activation of the STING signaling pathway in hepatic macrophages (IMAGE)

Xia & He Publishing Inc.

Activation of the STING signaling pathway in hepatic macrophages

Caption

AKT, protein kinase B; BAX, B-cell lymphoma-2-related protein X; cGAMP, cyclic-guanosine monophosphate-adenosine monophosphate; cGAS, cGAMP synthase; dsDNA, double-strand DNA; ER, endoplasmic reticulum; GLUT2, glucose transporter 2; IFNs, interferons; IκBα, inhibitor nuclear factor kappa B alpha; IL-6, interleukin-6; IKK, IκB-kinase; IRF3, interferon regulatory factor 3; IRS-1, insulin receptor substrate 1; JNK, c-jun N-terminal kinase; LDs, lipid droplets; MTORC1, rapamycin target protein complex 1; NF-κB, nuclear factor-kappa B; PI3K, phosphoinositide 3 kinase; RRAGA, ras-related GTP binding A; RRAGC, ras-related GTP binding C; SQSTM1, sequestosome1; STING, stimulator of interferon gene; TBK1, TANK binding kinase 1; TNF-α, tumor necrosis factor-alpha.

Credit

Lin Cao, Shaofeng Xie, Shaofeng Xie, Zhili Zhang Chen

Usage Restrictions

Credit must be given to the creator. Only noncommercial uses of the work are permitted.

License

CC BY-NC

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