Biomimetic hepatic lobules from three-dimensional imprinted cell sheets (IMAGE)
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Inspired by hepatic lobules, a novel artificial liver was developed by assembling morphological cell sheets with high accuracy in terms of cell type, density, and distribution. By simulating the spatial niche of liver cells, the liver cell sheets were stacked and printed in a spatial manner to construct hollow hexagonal prism-shaped liver microunits. After introducing endothelial cells, bioengineered liver lobules with vascularized channels were obtained and could be used for drug screening in liver chips. Furthermore, by assembling the vascularized bioengineered liver lobules into enlarged physiological structures, they can enhance the liver's regenerative capacity. This printing and assembly strategy of cell sheets mimicking liver lobule structures opens up new pathways for bioengineered liver development.
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