Microbiota changes in esophageal cancer. (IMAGE)

China Anti-Cancer Association

Microbiota changes in esophageal cancer.

Caption

Microbiota changes in esophageal cancer. The microbiota of the distal esophagus was influenced by acid reflux from the stomach. Acid reflux leads to inflammation and mucosal damage, resulting in the change of microbiome in the distal esophagus. This process allows the columnar epithelium to replace the original squamous epithelium of the esophagus, which can then progress to BE and EAC. The microbiota in the upper part of the esophagus is influenced by oral resident flora, in which P. gingivalis promotes the development of ESCC. BE, Barrett’s esophagus; EAC, esophageal adenocarcinoma; EC, esophageal cancer; ESCC, esophageal squamous cell carcinoma.

Credit

Cancer Biology & Medicine

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CC BY

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