Decoding the Complex Genetic Network of Antimicrobial Resistance in Campylobacter jejuni Using Advanced Gene Network Analysis (IMAGE)
Caption
The study focused on tetracycline resistance genes tetO and tetM. By employing phylogenetic tree analysis, this research has provided valuable insights into the genetic landscape and variants associated with C. jejuni. The investigation highlighted the key hub genes such as rplE, rplV, rplG, and others, revealing their integral roles in AMR through GO keywords such as gene expression, cellular biosynthetic processes, and RNA binding. Crucially, this study highlighted the significance of the rpl gene in driving the AMR phase of C. jejuni. These hub genes, exhibiting a high degree of clustering with their functional partners, have emerged as potential drug targets. The study’s findings raise hope that targeting these genes could pave the way for innovative treatments combating AMR in C. jejuni infections. This comprehensive exploration of genetic and functional aspects offers valuable insights into the complex dynamics of AMR, providing a foundation for future therapeutic interventions and strategies in the ongoing battle against antibiotic resistance in C. jejuni.
Credit
Karthick Vasudevan, Prasanna Kumar Selvam
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CC BY-NC