Cover Image 1000x600 (IMAGE) European Molecular Biology Laboratory Caption Creative depiction of the epigenetic editing toolkit: each building represents the epigenetic state of a single gene (dark windows are silenced genes, lit up windows are active genes). The crane illustrates the epigenetic editing system which enables de novo deposition of chromatin marks on any genomic location. Credit Marzia Munafò Usage Restrictions Credit must be given to the creator. Only noncommercial uses of the work are permitted. Adaptations must be shared under the same terms. License CC BY-NC-SA Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.