wacker nature (IMAGE)

The Mount Sinai Hospital / Mount Sinai School of Medicine

wacker nature

Caption

Mount Sinai researchers took detailed pictures of the serotonin receptor and clinically-validated drug target 5-HT1A using cryo-electron microscopy to show how the psychedelics LSD and 5-MeO-DMT and a 5-HT1A-selective 5-MeO-DMT derivative (4-F, 5-MeO-PyrT) bind. The team further discovered that 4-F, 5-MeO-DMT has antidepressant effects in mouse models mediated by 5-HT1A, which potentially contribute to the therapeutic effects of psychedelics observed in clinical studies.

Credit

Audrey Warren, PhD candidate and Daniel Wacker. PhD, Assistant Professor of Pharmacological Science and Neuroscience at Icahn Mount Sinai

Usage Restrictions

None

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.