The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). (IMAGE)

China Anti-Cancer Association

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME).

Caption

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens, T cell migration and infiltration, and T cell recognition and cytotoxicity. The cGAS-STING pathway also regulates tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), natural killer (NK) cells, B cells, and cancer-associated fibroblasts (CAFs).

Credit

Cancer Biology & Medicine

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