Figure 1 BET inhibition is synthetic lethal to OXPHOS blockage in liver cancer. (IMAGE)

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Figure 1 BET inhibition is synthetic lethal to OXPHOS blockage in liver cancer.

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Figure 1 BET inhibition is synthetic lethal to OXPHOS blockage in liver cancer. Left: GDH1-dependent glutamine metabolic remodeling upon BET inhibition. Right: “Synthetic lethality” targeting OXPHOS and BET proteins extends the survival of HCC-bearing mice.

Credit

Wen Mi, Jianwei You, Liucheng Li, Lingzhi Zhu, Xinyi Xia, Li Yang, Fei Li, Yi Xu, Junfeng Bi, Pingyu Liu, Li Chen, Fuming Li

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