Illustration of the anticoagulant supramolecule (IMAGE)
Caption
The image illustrates the combined action of two peptide molecules cooperating to inhibit thrombin. The antidote PNA (peptide nucleic acid) dissociates the two molecules, which ‘switches off’ the anti-clotting action of the combined molecule.
The blue molecule is the peptide fragment derived from the tsetse fly, the red is the active site binder with the ketobenzothiazole fragment. They are ‘joined’ by PNA, non-convalent bonding.
Credit
Millicent Dockerill and Nicolas Winssinger/University of Geneva
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