MAT2A (IMAGE) InSilico Medicine Caption MAT2A is an enzyme that plays an essential role in cell function and survival and the primary producer of S-adenosylmethionine (SAM), the universal methyl donor. Inhibition of MAT2A reduces the level of SAM, and ultimately inhibits the proliferation of MTAP-/- cancers. Credit Insilico Medicine Usage Restrictions none License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.