A schematic diagram showing the mechanisms underlying MALAT1-related chemotherapeutic resistance associated with blood cancer (IMAGE)
Caption
Recent studies have shown that an abnormally high expression of MALAT1 in blood cancer cells could aid the chemotherapeutic resistance development through multiple intermolecular interactions. Although researchers first identified the role of MALAT1 in patients with non-small-cell lung cancer, it has recently garnered interest in blood cancer owing to a large body of evidence implicating its pathogenic role when overexpressed in cancer cells. Now, in a Chinese Medical Journal review, researchers from Sichuan University, China, reviewed salient features of MALAT1 in blood cancer, from its disease-aggravating nature to its potential as a therapeutic target.
Credit
Chinese Medical Journal
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