Modeling viral evolution: A novel SIRSVIDE framework with application to SARS-CoV-2 dynamics (IMAGE)
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The SIRSVIDE model developed by Professor Jian Lu's research group provides a comprehensive framework for studying viral epidemiology and evolutionary dynamics. The simulation results reveal that under specific conditions, viral populations tend to evolve towards increased transmissibility, enhanced immune escape capability, and reduced pathogenicity, with large susceptible host populations and high mutation rates being the key factors driving this evolutionary trend. These findings provide new insights into the evolutionary patterns of SARS-CoV-2 and other viruses.
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Jian Lu, School of Life Sciences, Peking University
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