A proposed model showing how LSD1 and autophagy jointly downregulate the level of WT1 to ensure FSHR expression and thus support the response of GCs to FSH induction. (IMAGE)

Science China Press

A proposed model showing how LSD1 and autophagy jointly downregulate the level of WT1 to ensure FSHR expression and thus support the response of GCs to FSH induction.

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this study revealed the LSD1-induced gene expression profiles that promote FSH responsiveness in GCs by regulating autophagy and repressing Wt1 expression during antral follicles formation.

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