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National University of Singapore, Yong Loo Lin School of Medicine

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Young adults had higher proportion of a specific T cell, the interferon-γ(IFNγ)-secreting CD4+ T-cells, which is associated with more antibody responses and stronger virus neutralisation. Conversely, this relationship was negative in older adults, suggesting that older adults’ relative IFNγ-secreting CD4+ T-cell deficiency might explain their weaker immune response to vaccination

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Diego Araujo, National University Health System

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