Progress in drug discovery based on targets with favorable LOF variants identified by WES, WGS, and GWAS. (IMAGE)

Sichuan International Medical Exchange and Promotion Association

Progress in drug discovery based on targets with favorable LOF variants identified by WES, WGS, and GWAS.

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Targets primarily include PCSK9, ANGPTL3, HSD17B13, KHK, ASGR1, GPR75, CIDEB, and INHBE. Drug types primarily include small molecules, monoclonal antibodies, RNAi, and CRISPR gene editing therapies. The timeline is determined by the status of the target’s current investigational drugs.

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