Metabolic interventions for improving CAR-T cells efficacy in tumor microenvironment. (IMAGE)

Cactus Communications

Metabolic interventions for improving CAR-T cells efficacy in tumor microenvironment.

Caption

Chimeric antigen receptor T (CAR-T) cell therapy effectively treats hematological tumors but struggles due to metabolic challenges in the tumor microenvironment. Tumor cells disrupt metabolic processes and compete with T cells for nutrients, suppressing immune response. A Chinese Medical Journal article discusses these challenges and proposes innovative strategies to enhance CAR-T cell efficacy by targeting metabolism. Improving mitochondrial metabolism can boost CAR-T cell activity, as depicted in the accompanying figure.

Credit

Chinese Medical Journal

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License

CC BY-NC-ND

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