CAR transfer, a new method for in vivo CAR-T production. (IMAGE)

Science China Press

CAR transfer, a new method for in vivo CAR-T production.

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The virus-mimetic fusogenic nanovesicle (FuNV) can efficiently fuse with T cell in vivo, thereby delivering the loaded anti-CD19 (αCD19) chimeric antigen receptor (CAR) onto T cells to produce αCD19 CAR-T cells. These in vivo engineered αCD19 CAR-T cells show effective inhibition of B-cell lymphoma.

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