Schematic diagram illustrating the possible mechanism of SMURF1 in serum iron overload (Created with bioRender.com) (IMAGE)

Xia & He Publishing Inc.

Schematic diagram illustrating the possible mechanism of SMURF1 in serum iron overload (Created with bioRender.com)

Caption

BMP, bone morphogenetic protein; BMPR, bone morphogenetic protein receptor; HAMP, hepcidin; HFE, hereditary hemochromatosis protein; HJV, hemojuvelin; Holo-Tf, holo-transferrin; SMAD1, SMA and mothers against decapentaplegic homolog 1; SMURF1, E3 ubiquitin-protein ligase1; TFR2, transferrin receptor protein 2.

Credit

Anjian Xu, Jidong Jia, Ning Zhang, Pengyao Yang

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Credit must be given to the creator. Only noncommercial uses of the work are permitted.

License

CC BY-NC

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