Proposed model for CA439-colistin potentiation. (IMAGE)

University of Eastern Finland

Proposed model for CA439-colistin potentiation.

Caption

Quinazoline CA439 enhances the action of the antimicrobial peptide colistin through a triple mechanism of action that involves: 1, permeabilization of the bacterial outer membrane; 2, down-regulation of polymyxin resistance genes through the PhoP/PhoQ-PmrA/PmrB cascade; 3, alteration of electrochemical potential of the bacterial inner membrane.

Credit

C. Asquith.

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