Synaptic degeneration (IMAGE)
Caption
Art shows synaptic degeneration triggered by stalled γ-secretase enzyme-substrate complexes. Proteolytic processing by membrane-embedded γ-secretase produces amyloid β-peptides that are implicated in the pathogenesis of Alzheimer’s disease. Dominant mutations in genes encoding the enzyme and substrate cause hereditary, early-onset forms of the disease. Devkota and colleagues report that such mutations reduce proteolytic function by stabilizing enzyme-substrate complexes and that such stalled
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Julia J. Wolfe
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