Engineered mitochondrial DNA editing enzyme with improved enzymatic activity and precision. (IMAGE)

Korea University College of Medicine

Engineered mitochondrial DNA editing enzyme with improved enzymatic activity and precision.

Caption

Scientists improved adenine base editing in mitochondrial DNA using engineered transcription activator-like effector-linked deaminases (TALEDs). The engineered TALEDs minimize off-target gene edits, offering the potential to treat mitochondrial genetic disorders affecting thousands worldwide.

Credit

Associate Professor Hyunji Lee from Korea University

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