Image 1 (IMAGE)

National University of Singapore, Yong Loo Lin School of Medicine

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Caption

An illustration of computer modelled structures of complexes formed between RXFP3 and relaxin-3 or relaxin-3 B-chain stapled peptides.

(A) shows relaxin-3 binding to RXFP3, while (B to D) show different stapled relaxin-3 B-chain peptides binding to RXFP3. Binding of the various peptides at the top of the receptor outside the cell, results in different configurations at the bottom of the receptor inside the cells. It is proposed that these different configurations differentially trigger the RXFP3 signalling pathways inside the cell.  

Credit

Credit: NUS Yong Loo Lin School of Medicine and University of Colombo, Sri Lanka

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