Unexpectedly low drug sensitivity to platinum agents and PARP inhibitors in cancer cell lines. (IMAGE)

Kindai University

Unexpectedly low drug sensitivity to platinum agents and PARP inhibitors in cancer cell lines.

Caption

A comprehensive analysis of drug sensitivity data reveals that cancer cell lines with homologous recombination deficiency are not particularly vulnerable to platinum agents and PARP inhibitors in vitro. This is in stark contrast to clinical results, suggesting that experiments on cancer cell lines may not be a reliable way to assess the efficacy of drug candidates.

Credit

Noriomi Matsumura from Kindai University

Usage Restrictions

Credit must be given to the creator.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.