Protein surface and ribbon (IMAGE)

City of Hope

Protein surface and ribbon

Caption

Protein surface (left) and ribbon (right) models of integrin αV’s β-propeller domain illustrate the capacity of Cpd_AV2 (yellow) in disrupting the interaction between integrin β5’s βA loop (cyan; green indicates the key interacting residue lysine 287) and integrin αV. The integrin αV’s β-propeller domain is colored by normalized CRISPR-tiling score (NCS).

Credit

Chun-Wei (David) Chen, Ph.D. / City of Hope

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