Mitochondrial dysfunction causes an extensive disorganization of the Golgi apparatus leading to impaired trafficking and accumulation of dietary lipids within lipid droplets in enterocytes. (IMAGE)
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Pictures show small intestinal villi from wild type (top) and enterocyte-specific DARS2 knockout mice (bottom) stained for PLIN2 (yellow), TGN38 (red), E-cadherin (green) and DNA (DAPI, blue).
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Chrysanthi Moschandrea
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