Multicompartment model of beta-amyloid turnover and cytotoxicity (IMAGE)

Bentham Science Publishers

Multicompartment model of beta-amyloid turnover and cytotoxicity

Caption

The image shows the multicompartment model of beta-amyloid turnover and cytotoxicity (A) that resolves two central paradoxes of amyloid biomarkers – a high probability of AD diagnosis in patients with a high density of non-toxic amyloid deposits (PET signal) and a low concentration of toxic soluble beta-amyloid in cerebrospinal fluid (CSF-Aβ42). Mathematical formalization of this concept reproduces clinical data. A patient's current probability of AD diagnosis is a function of their amyloid deposit density and CSF-Aβ42. It is shown as a heat map with an overlay showing the distribution of clinical data (B). Yellow circles (AD) – data points corresponding to AD patients, green circles (NC) – to patients with normal cognition.

Credit

Dr. Dmitry V. Zaretsky and Bentham Science Publishers

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The image rights belong to Dr. Dmitry V. Zaretsky and Bentham Science Publishers

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