Mouse heart muscle cells with introduced PKP2 (IMAGE)

Hubrecht Institute

Mouse heart muscle cells with introduced PKP2 — Caption

Microscopy image showing heart muscle cells (gray) in a mouse heart. The plakophilin-2 protein (green) is present in the desmosomes connecting adjacent heart muscle cells. After introduction of the healthy PKP2 gene, extra plakophilin-2 (red) is present in the cells (visible as yellow in places where green and red overlap). This localizes to the desmosomes, leading to their structural recovery.

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Credit: Eirini Kyriakopoulou. Copyright: Hubrecht Institute.

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