Spatial transcriptomics in development and disease (IMAGE)

Sichuan International Medical Exchange and Promotion Association

Spatial transcriptomics in development and disease

Caption

Spatial transcriptomics techniques facilitate the study of tumor microenvironment heterogeneity and tumor heterogeneity. a ST examines the diversity within cancer-associated fibroblasts and immunosuppressive molecules within the microenvironment of breast cancer. b ST enables the identification and comprehensive exploration of unique tumor microenvironment regions, such as the tumor interface and tertiary lymph nodes. c ST analyzes the spatial distribution of PDAC-associated heterogeneity, identifying highly heterogeneous and transitional PDAC subpopulations. d ST applied to breast cancer biopsy identified that tumor cells harboring GATA3 mutations became more invasive, revealing the spatial heterogeneity of breast cancer

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