Covalent Inhibition of an Ibrutinib-Resistant BTK Mutant (IMAGE)

Kyoto University

Covalent Inhibition of an Ibrutinib-Resistant BTK Mutant

Caption

Lysine target engages with an irreversible inhibitor. The reactive ArNASA group chemically reacts with the protein's amino acids to form a covalent bond, irreversibly inhibiting protein activity. 

 

Credit

KyotoU/Jake Tobiyama/Tomonori Tamura

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