Loss of Daam1 & Rnf43 in organoids and intestine (IMAGE)

IMBA- Institute of Molecular Biotechnology of the Austrian Academy of Sciences

Loss of Daam1 & Rnf43 in organoids and intestine

Caption

Top: Intestinal stem cells lacking Daam1 (left) or Rnf43 (right) form tumor-like organoids. 

Bottom: Intestines lacking Daam1 do not form ectopic Paneth cells, a type of secretory cells (left), while intestines lacking Rnf43 form ectopic Paneth cells (green, right).   

© Gabriele Colozza/IMBA 

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© Gabriele Colozza/IMBA

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