Annex (IMAGE)

SingHealth

Annex

Caption

The illustration below summarises the collaborative efforts between NHCS and Novoheart to create Asia's first bioengineered 'Human Heart-in-a-Jar':

  • Stages 1 to 3: NHCS researchers retrieve a sample of the Teart failure patient's blood from NHCS Biobank to create patient-specific beating heart cells.
  • Stages 4: With the patient-specific beating heart cells obtained in stage 3, Novoheart will create a miniature heart model, 'Human Heart-In-A-Jar', unique to this heart failure patient. The 'Human Heart-In-A-Jar' will reproduce key features seen in HFpEF patients, including relaxation defects, fibrosis, and hypertrophy.
  • Stage 5 to 6: NHCS and Novoheart will discover new therapies for heart failure patients through testing patient-specific drugs on 'Human Heart-in-a-Jar' to ensure safety and efficacy before applying on actual patients.

Credit

National Heart Centre Singapore

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