Construction and Concept of B-BiTE (IMAGE)

Ehime University

Construction and Concept of B-BiTE

Caption

A monoclonal antibody can activate human NK cells, and a BiTE can stimulate human T cells against myeloma cells, separately. In contrast, the B-BiTE possesses two single chain variable fragments specific for the Fc region of the human IgG and human CD3 molecule. As a result, an mAb/B-BiTE complex safely and effectively targeted myeloma cells and other tumor cells via dual-lymphoid activation mediated by human T cells as well as NK cells.

Credit

This research was originally published in Blood. Konishi T, et al. Reinforced anti-myeloma therapy via dual-lymphoid activation mediated by a panel of antibodies armed with Bridging-BiTE. Blood. 2023. © by the American Society of Hematology.

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