Opportunities and challenges for hepatitis B cure. (IMAGE)

First Hospital of Jilin University

Opportunities and challenges for hepatitis B cure.

Caption

Particularities of the HBV cycle that favour the development of chronic infection (centre), the clinical challenges stemming from these biological characteristics (top) and the opportunities currently under development to achieve the goal of HBV cure (bottom). cccDNA, covalently closed circular DNA; 3D, three-dimensional; DCs, dendritic cells; FNAs, fine-needle aspirates; HBe, hepatitis B e; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; MPs, macrophages; NUCs, nucleos(t)ide analogues; PCLS, precision-cut liver slices; pegIFN-α, pegylated interferon alpha; PHH, primary human hepatocytes; WHV, woodchuck hepatitis virus.

Credit

By Armando Andres Roca Suarez and Fabien Zoulim

Usage Restrictions

Credit must be given to the creator. Only noncommercial uses of the work are permitted.

License

CC BY-NC

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