Different routes of entry into human cells for SARS-CoV-2 and HKU1 (IMAGE)

Institut Pasteur

Different routes of entry into human cells for SARS-CoV-2 and HKU1

Caption

SARS-CoV-2 binds to ACE2 protein. The protease TMPRSS2 then cleaves the spike to enable viral fusion and entry into the target cell. HKU1 binds directly to TMPRSS2 in order to enter the cell without using ACE2.

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© Institut Pasteur

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