Fas-mediated 'bystander' killing (IMAGE)

University of California - Davis Health

Fas-mediated 'bystander' killing

Caption

Antigen-positive tumor cell (blue, left) is a direct target of CAR T-cells (light red) due to high-affinity antibody-antigen contacts. On the contrary, an antigen-negative tumor cell (light golden, right) is killed by Fas-mediated "bystander" killing. Cancer patients with high Fas-expression are expected to respond significantly better to immunotherapies.

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UC Davis

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