The dual suppressive effect of gingipain on both xenophagy and autophagy (IMAGE)

Tokyo Medical and Dental University

The dual suppressive effect of gingipain on both xenophagy and autophagy

Caption

Gingipain released by P.g. cleaves VAMP8, thereby inhibiting autophagy through preventing autophagosomes-lysosome fusion, which causes cardiac dysfunction.

Credit

Department of Cardiovascular Medicine, TMDU

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