In vivo fate of nanovaccines and strategies for machine learning-guided nanovaccine design (IMAGE)
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(a) Anionic Lipo-ORG enabled effective access to lymphatics and high accumulation in lymph nodes. Effective cellular entry and endosome escape of mRNA and cGAMP was achieved in DCs and potentiated antigen presentation to T cells. Tumor antigens were presented after the release of mRNA. cGAMP activated STING pathway to trigger IFN-I, which amplified the innate and adaptive immune responses. T cell inflammation and immune memory effect were initiated for tumor elimination, which was further improved when combined with anti-PD-L1 therapy. (b) A brief outlook upon further optimization of nanovaccines for lymph node targeting and efficient delivery through machine learning techniques.
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