Sleep-Deprived Cells Can't Clear Oxidants (IMAGE)
Caption
Adequate vs. Poor Sleep. The researchers traced the absence of the antioxidant response in sleep-deprived cells to a cellular factor, NRF2, that becomes trapped in the cytoplasm. When damaging oxidants accumulate in cells, NRF2 usually moves into the nucleus (blue) to turn on the antioxidant response. After chronic sleep restriction (right image) the Cullin3 protein holds NRF2 (yellow) in the cytoplasm.
Credit
Columbia University Irving Medical Center
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