Schematic diagram showing PRMT1-enhanced gastric cancer metastasis mediated by the β-catenin signaling pathway in vitro and in vivo. (IMAGE)

Chongqing Medical University

Schematic diagram showing PRMT1-enhanced gastric cancer metastasis mediated by the β-catenin signaling pathway in vitro and in vivo.

Caption

In the cytoplasm, KTN1 inhibits K48-linked polyubiquitination of PRMT1 by decreasing the interaction between TRIM48 and PRMT1. Then, in the nucleus, PRMT1 recruits MLXIP to the β-catenin promoter and transcriptionally activates the β-catenin signaling pathway. PRMT1 promotes gastric cancer cell proliferation, migration, and invasion of in vitro and tumor growth and metastasis in vivo.

Credit

Genes & Diseases

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