The molecular mechanism and therapeutic strategy of miR-18a-5p mediating osteoblastic lesions in PCa bone metastasis. (IMAGE)
Caption
The molecular mechanism and therapeutic strategy of miR-18a-5p mediating osteoblastic lesions in PCa bone metastasis. PCa-EXO transports miR-18a-5p into osteoblasts, where miR-18a-5p targets the Hist1h2bc gene and promotes Ctnnb1 gene expression, thereby positively regulating the Wnt/β-catenin signaling pathway and leading to osteoblastic lesions. Antagomir-18a-5p could effectively alleviated osteoblastic lesions.
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Genes & Diseases
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