Perineuronal nets (IMAGE)

Cold Spring Harbor Laboratory

Perineuronal nets

Caption

Inside mouse mothers’ hearing center, parvalbumin interneurons (PVin, magenta) are surrounded by perineuronal nets (PNNs, green). Upon hearing crying pups, mice with PVin lacking the MECP2 protein (bottom row) experience a dramatic increase in PNN number and intensity, especially on day one of the experiment (middle column). This manifests as parental neglect.

Credit

Shea lab/Microscopy Core Facility/Cold Spring Harbor Laboratory

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