Enterococcus faecalis 2001 is a probiotic lactic acid bacterium and has been used as a biological response modifier (BRM). From physiological limitation of bacterial preservation in storage and safety, the live E. faecalis 2001 has been heat-treated and the BRM components containing high level of β-glucan, named EF-2001, were prepared.
Multidrug resistance of microbes poses a serious global threat to human health. Resistant strains of Klebsiella pneumoniae significantly reduce therapeutic options for the treatment of potentially fatal pneumonia or sepsis. Pavel Kovarik and his team now report new insights into how immune cells communicate at the site of infection and join forces in the fight against Klebsiella infections. Their results might be used for the development of alternatives to ineffective anti-microbial drugs.
RUDN University chemists synthesized new isoquinoline derivatives. Due to their biological activity, these compounds may be applicable in new drugs, from antispasmodics to bactericidal agents. In addition, in the future they may show effectiveness in the treatment of Alzheimer's disease. The scientists presented the results of their experiments in Mendeleev Communications.
Researchers have shown that use of the dietary supplement yerba mate over an extended period had significant effects on body weight and weight gain and was associated with lower levels of blood lipids and insulin in obese mice fed a high-fat diet.
A new shape-shifting polymer can target and kill Helicobacter pylori bacteria in the stomach without killing helpful bacteria in the gut. Such a treatment could improve the digestive health of billions of people worldwide who contract H. pylori infections. The antimicrobial agent morphs into a bacterial hole-puncher in the stomach's acidic environment and reverts to an amorphous, inactive structure when it reaches the higher pH environment of the small intestine.
Manganese dioxide could make the preparation of micromotors increasingly cost-effective, opening up new avenues for their use, according to a new study from the University of Eastern Finland.
NitroSynapsin is intended to restore an electrical signaling imbalance in the brain found in virtually all forms of autism spectrum disorder (ASD).
New research from the University of Michigan Life Sciences Institute is building a bridge from nature's chemistry to greener, more efficient synthetic chemistry.
Researchers from RUDN University and Institute of Biomedical Chemistry of the Russian Academy of Sciences have identified an alternative mechanism for the effective antitumor drug -- an enzyme called L-asparaginase. Some isoenzymes of L-asparaginase block the growth of telomeres (region of repetitive nucleotide sequences at each end of a chromosome) on DNA molecules, and this limits the number of divisions of a cancer cell. This effect is reported in the Biochemical and Biophysical Research Communications.
Celgene Corporation recently announced results from two phase 3 trials evaluating the efficacy and safety of the drug ozanimod. Ozanimod was invented by scientists at The Scripps Research Institute (TSRI).