Alzheimer's disease (AD) is the most common cause of dementia in elderly populations. Changes in the expression of the amyloid precursor protein (APP)-cleaving enzymes directly affect the formation of amyloid beta (Aβ) plaques, a neuropathological hallmark of AD.BACE1 mRNA level in AD subjects was significantly higher than those of healthy controls, whereas ADAM10 level was significantly lower in the AD subjects.
Patients who died of IS the most common type of dementia was vascular dementia while those died from other causes were most often diagnosed with Alzheimer's dementia (AD). Patients who died from IS and were registered in Riksstroke had higher MMSE score compared to other groups. Patients who died from IS took more cardiovascular medications. There were no differences in the use of antipsychotics, antidepressants, acetylcholinesterase inhibitors, memantine, anxiolytics, or hypnotics between the groups.
S. aureus under the biofilm mode of growth is often related to several nosocomial infections, more frequently associated with indwelling medical devices (catheters, prostheses, portacaths or heart valves).The present paper will provide an overview on the activity and potential applications of RIP as biofilm inhibiting compound, useful in the management of S. aureus biofilm infections.
Nanomedicine is a field of science that employs materials in the nanometer scale.Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common disorders worldwide, becoming a serious economic burden and public health problem.In this review, we have highlighted the potential of lipid nanoparticles in reaching the brain, a challenging task in modern medicine.
Recently, electrospun polymeric nanofibers have proven to be an interesting strategy for drug delivery systems application.This review presents an overview of the reported drugs loaded into polymeric nanofibers, to be used as drug delivery systems.
Vinorelbine bitartrate (VRL), a semi synthetic vinca alkaloid approved for breast cancer, has been proven to be beneficial as first line and subsequent therapies. However, its hydrophilic and thermo labile nature provides hindrance to oral clinical translation. The current work focused on the application of DOE a modern statistical optimization tool for the development and optimization of a solid lipid nanoparticle (SLN) formulation that can encapsulate hydrophilic and thermolabile Vinorelbine bitartrate (VRL) to a maximum extent without compromising integrity and anticancer activity of the drug.
MIT researchers have designed an ingestible capsule that can be controlled using Bluetooth wireless technology. Their capsule, which can be customized to deliver drugs, sense environmental conditions, or a combination of those functions, can reside in the stomach for at least a month, transmitting information and responding to instructions from a user's smartphone.
A new study published ahead-of-print by SLAS Discovery describes an evaluation of microplate-based high-throughput cellular thermal shift assay (CETSA HT) performed at AstraZeneca to assess its suitability and reliability for application to early drug discovery campaigns.
Louis Populin and collaborators at the University of Wisconsin-Madison collaborators published a study this week in the Journal of Neuroscience describing increased connections between key parts of the brains of monkeys who have taken methylphenidate (Ritalin).
The major degradation products of pralatrexate drug product formed under hydrolytic and light stress conditions were identified, synthesized and characterized using advanced spectroscopic techniques such as NMR, HR-MS and IR.