News by Subject Chemistry & Physics

A new family of drugs which inhibit the activity of a protein associated with prostate and other cancers has been reported by scientists from the University of Bath.

C-Path and NORD launched the Rare Disease Cures Accelerator-Data and Analytics Platform (RDCA-DAP) in Rockville, MD on Tuesday, Sept. 17. The platform, funded by a cooperative agreement through the Food and Drug Administration, [Critical Path Public-Private Partnerships Grant Number U18 FD005320], will provide data and analytics to aid in the understanding of rare diseases and to inform long-term drug development and support innovative trial designs.

Proteins keep our organs functioning, egulate our cells and are the targets for medications that treat a number of diseases, including cancers and neurological diseases. Proteins need to move in order to function. But, because the technology they used to watch proteins doesn't allow it, scientists still know very little about such motions at speeds slower than a nanosecond. That changed last month when researchers showed they had found a way

In a study published in Scientific Reports, University of Alberta researcher Jack Jhamandas and his team found two short peptides, or strings of amino acids, that when injected into mice with Alzheimer's disease daily for five weeks, significantly improved the mice's memory. The treatment also reduced some of the harmful physical changes in the brain that are associated with the disease.

This article describes a platform that combines artificial intelligence-driven synthesis planning, flow chemistry and a robotically controlled experimental platform to minimize the need for human intervention in the synthesis of small organic molecules. An AI-guided approach is being used to address similar challenges with peptide synthesis and purification at Mytide Therapeutics. AI is enabling end-to-end peptide manufacturing in an autonomous fashion, including optimized reaction planning, real-time process optimization for in-sequence process modifications and robotics.

Four substances isolated from Mimosa caesalpiniifolia were found to be more effective against thrush and candida than was fluconazole. Brazilian researchers are developing an ointment.

Marcos G. Suero and his research group at the Institute of Chemical Research of Catalonia (ICIQ) present a new reaction that allows for the edition of organic molecule's skeletons, opening up new avenues of research.

An international research team is perfecting a method to predict the potential clinical implications of new drugs before clinical trials even start.