Combinations of cancer drugs can be quickly and cheaply tested on tumour cells using a novel device developed by EMBL scientists. The research, reported in Nature Communications on June 22, marks the latest advancement in the field of personalised medicine.
New research, published in the journal Nature Communications, shows that it may be possible to freeze cancer cells and kill them where they stand.
This review paper will cover recent advances in the development of chemotherapeutic agents against several metabolic targets for cancer therapy, including glucose transporters, hexokinase, pyruvate kinase M2, glutaminase, and isocitrate dehydrogenase.
A team of researchers at Sanofi and Mainz University finds no positive action of isomers of the fatty acid derivatives 5- and 9-PAHSA in diabetes models.
The work has important implications for understanding how human cancer cells develop resistance to natural product-based chemotherapies.
Opioids are powerful painkillers that act on the brain, but they have a range of harmful side effects including addiction. Researchers from the Max Planck Institute of Biochemistry in collaboration with researchers from the Medical University of Innsbruck, Austria, University of Innsbruck, and the Lewis Katz School of Medicine at Temple University, have developed a tool that gives deeper insights into the brain's response to opioids.
UBC researchers have matched small proteins, called peptides, with antibiotics so they can work together to combat hard-to-treat infections that don't respond well to drugs on their own.
A new study shows that a caffeine concentration equivalent to four cups of coffee promotes the movement of a regulatory protein into mitochondria, enhancing their function and protecting cardiovascular cells from damage. The work, by Judith Haendeler and Joachim Altschmied of the Medical Faculty, Heinrich-Heine-University and the IUF-Leibniz Research Institute for Environmental Medicine in Duesseldorf, Germany, and colleagues, publishes June 21 in the open access journal PLOS Biology.
Researchers have developed a new method for correcting the errors that creep into DNA barcodes -- labels used in a wide range of biological experiments -- yielding far more accurate results and paving the way for more ambitious medical research in the future.
In recent articles, scientists optimize experimental design for understanding potential chemotherapeutic agents, delve into crop responses to salt-water stress, and present a better way to ensure consistency in long-term proteomics studies.