Enterococcus faecalis 2001 is a probiotic lactic acid bacterium and has been used as a biological response modifier (BRM). From physiological limitation of bacterial preservation in storage and safety, the live E. faecalis 2001 has been heat-treated and the BRM components containing high level of β-glucan, named EF-2001, were prepared.
Researchers at the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine have developed a computer program to find new indications for old drugs. The computer program, called DrugPredict, matches existing data about FDA-approved drugs to diseases, and predicts potential drug efficacy. In a recent study published in Oncogene, the researchers successfully translated DrugPredict results into the laboratory, and showed common pain medications--like aspirin--can kill patient-derived epithelial ovarian cancer cells.
A new study shows as many as one in 20 children were still receiving codeine to treat pain after tonsil and adenoid surgery, two years after federal regulators warned doctors that prescribing the opioid to kids after the routine surgeries could be fatal.
A discovery might help designers of miniature 'lab-on-a-chip' technologies to grow three-dimensional colonies of cancer cells inside a chip's tiny chambers, rather than the merely two-dimensional colonies that they generally can culture now. Chips with 3-D cell arrays could furnish more realistic biological environments for drug testing.
Multidrug resistance of microbes poses a serious global threat to human health. Resistant strains of Klebsiella pneumoniae significantly reduce therapeutic options for the treatment of potentially fatal pneumonia or sepsis. Pavel Kovarik and his team now report new insights into how immune cells communicate at the site of infection and join forces in the fight against Klebsiella infections. Their results might be used for the development of alternatives to ineffective anti-microbial drugs.
New research could boost the development of a more potent vaccine against the global killer.
Scientists on the Florida campus of The Scripps Research Institute (TSRI) have developed new opioid pain relievers that reduce pain on par with morphine but do not slow or stop breathing -- the cause of opiate overdose.
The first genetic mutation that appears to protect against multiple aspects of biological aging in humans has been discovered in an extended family of Amish living in Indiana, reports a new study. An experimental 'longevity' drug that recreates the effect of the mutation is now being tested in human trials to see if it provides protection against aging. Indiana Amish with the mutation live 10 percent longer, are protected from diabetes and have a younger cardiovascular system.
By focusing on genetic variations within a primary tumor, differences between the primary and a metastatic tumor, and additional diversity from tumor DNA in the blood stream, physicians can make better treatment choices for patients with gastric and esophageal adenocarcinoma. This study challenges current guidelines and supports evaluation of metastatic lesions and circulating tumor DNA.
A unique approach to targeting the abnormal T-cells that cause T-cell lymphomas could offer hope to patients with the aggressive and difficult-to-treat family of cancers, finds a study involving researchers from Cardiff University.