News by Subject Chemistry & Physics

A University of Houston College of Pharmacy associate professor has discovered a new biomarker in cancer stem cells that govern cancer survival and spread, and it's raising hope that drug discovery to kill cancer stem cells could follow suit.

A novel microfluidic device addresses one of the most costly steps in the engineered cell therapy manufacturing process, namely gene delivery. Deterministic mechanoporation, or DMP, uses fluid flow to pull each cell in a large population onto its own tiny needle. The flow is then reversed to release the cells from the needles, leaving a singular and precisely defined pore within each cell that allows for gene delivery. Eliminating viral vectors can substantially reduce cost.

There is a strong association between the number of fracture-associated drugs (FADs) older patients receive and their risk of sustaining a hip fracture, according to a new Dartmouth study.

A Purdue University team published a paper in the British Journal of Pharmacology examining the effects of kratom and the potential impacts on people with alcohol use disorder.

A randomized clinical trial in Australia tested whether a dose of naloxone administered through the nose was as effective as the same dose delivered by injection to reverse opioid overdose as measured by the need for a rescue dose delivered by injection 10 minutes after the initial treatment.

Children who have received radiotherapy for a brain tumor can develop cognitive problems later in life. In their studies on mice, researchers at Karolinska Institutet have now shown that the drug lithium can help to reverse the damage caused long after it has occurred. The study is published in the journal Molecular Psychiatry and the researchers are now planning to test the treatment in clinical trials.