Discoveries by two HHMI investigators show how proteins that organize into liquid droplets inside cells make certain biological functions possible.
Two receptors in the spinal cord and the right experimental drug: Researchers at the University of Zurich have discovered a new approach that suppresses itch. In a series of experiments in mice and dogs they successfully alleviated different forms of acute as well as chronic itch. For the latter, current treatment options are very limited.
A new study led by Ana Sebastião, group leader at Instituto de Medicina Molecular João Lobo Antunes and Professor of Faculdade de Medicina of Universidade de Lisboa (iMM, FMUL; Portugal) and her team in collaboration with researchers from the University of Lancaster (UK), shows that the long-term use of either cannabis or cannabis-based drugs impairs memory.
Newborn granule cells show high excitability that disappears as the cells mature. Little has been known about the mechanisms that create low excitability in mature cells or how excitability of the newborn granule cells changes over time. Now University of Alabama at Birmingham researchers have described key roles for G protein-mediated signaling and the late maturation of an ion channel during the differentiation of granule cells. Their study is published in The Journal of Neuroscience.
A team of UNLV, Tufts University, and international researchers has identified which brain proteins might be most influential in controlling neural activity associated with epilepsy and anxiety, paving the way for better prevention and treatments someday.
Ashleigh Schaffer, Ph.D., assistant professor of genetics at Case Western Reserve University School of Medicine, and a team of global genetics experts have discovered a genetic mutation and the faulty development process it triggers, causing a debilitating brain-based disorder in children.
A group of scientists from the Hong Kong University of Science and Technology employed a biochemical reconstitution approach to show that, both in solution and on supported membrane bilayers, multivalent interaction networks formed by major excitatory postsynaptic density (PSD) scaffold proteins led to formation of PSD-like assemblies via phase separation.
The same aspects of relatively recent evolutionary changes that make us prone to bad backs and impacted third molars may have generated long, noncoding stretches of DNA that predispose individuals to schizophrenia, bipolar disorder, and other neuropsychiatric diseases. A study publishing Aug. 9 in the American Journal of Human Genetics identifies an unusually lengthy array of tandem repeats found only within the human version of a gene governing calcium transport in the brain.
A study by University of Melbourne researchers reveals clinically relevant epileptic seizure prediction is possible in a wider range of patients than previously thought, thanks to the crowdsourcing of more than 10,000 algorithms worldwide.
Model system researchers have examined the factors that influence productive activity one year after traumatic brain injury (TBI).