A new chemical synthesis strategy to harvest the rich information found in natural products -- organic compounds isolated from natural sources -- has led to the identification of novel, simpler derivatives with potential to selectively protect neurons, important for neurodegenerative diseases like Alzheimer's disease, or to prevent the immune system from rejecting organ transplants, a Baylor-led study finds
Scientists used a compound found in a shrub native to Africa to reveal the three major shapes of the serotonin transporter, a protein in the brain linked to anxiety and depression. The discovery opens new avenues for developing medications to treat addiction.
There is now further evidence that a drug that is effective in treating the rare muscle-wasting disease spinal muscular atrophy (SMA) early in life may be associated with improvement in older children, according to a study published in the April 24, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.
A subset of the stem cells in hair follicles have the potential to regenerate the coating that insulates neurons in mice, reports Thomas Hornyak of the VA Maryland Health Care System and the University of Maryland School of Medicine and colleagues, in a new study published 24th April in PLOS Genetics. The study offers a new direction for finding therapeutic options for certain neurodegenerative diseases.
Obesity can break down our protective blood brain barrier resulting in problems with learning and memory, scientists report.
The loss of memory and cognitive function known to afflict survivors of septic shock is the result of a sugar that is released into the blood stream and enters the brain during the life-threatening condition.
Research by a Barrow Neurological Center scientist on mechanisms of dysfunctional RNA processing in ALS and frontaltemporal dementia (FTD) was published in the April issue of Acta Neuropathologica. The research was conducted by Dr. Rita Sattler and her graduate student Stephen Moore in her laboratory at the Department of Neurobiology at Barrow Neurological Institute, which is dedicated to understanding the mechanisms of disease in ALS, FTD and related neurodegenerative diseases.
A new study shows that a synthetic molecule developed by Oregon Health & Science University scientists stimulates repair of the protective sheath that covers nerve cells in the brain and spinal cord. The study demonstrates in mice that a synthetic molecule called sobetirome efficiently repairs damaged myelin without side effects.
Human perception is based on mathematically optimal principles, but the brain implements those principles imperfectly, suggests new research by Elina Stengård and Ronald van den Berg of the University of Uppsala, Sweden. They present their findings in PLOS Computational Biology.
Circulation and cellular activity were restored in a pig's brain four hours after its death, a finding that challenges long-held assumptions about the timing and irreversible nature of the cessation of some brain functions after death, Yale scientists report April 18 in the journal Nature.