Biologists from the Plant Physiology Laboratory at the University of Guam and neuroscientists from the Experimental Medicine Program at The University of British Columbia have published an update on the reputed environmental toxins that have been suspected of being involved in mammal neurodegeneration.
In the international prospective multicenter crossover LEADER-75 trial, comparison of reduced-dose gadobutrol and standard-dose gadoterate versus unenhanced imaging demonstrated noninferiority using 20% margin for three primary efficacy measures; mean readings differed by less than 1%, supporting equivalence using a narrow ±5% margin. Various secondary variables also supported non-inferiority of reduced-dose gadobutrol.
Cryo-electron microscopy and computer simulations uncover how a cellular protein helps transport omega-3 fatty acids to the brain and eye, with implications for drug development.
Case Western Reserve University researchers studying prions--misfolded proteins that cause lethal incurable diseases--have identified for the first time surface features of human prions responsible for their replication in the brain.
In primary microcephaly, the ballet of cell division is dysregulated, preventing proper brain development. Scientists (UNIGE) have demonstrated how the mutation of a single protein, WDR62, prevents the proper formation of the cable network responsible for separating genetic material into two. As cell division is then slowed down, the brain does not have time to build itself completely. These results shed new light on cell division, a phenomenon also involved in cancer development.
Researchers at the National Eye Institute (NEI) have determined how certain short protein fragments, called peptides, can protect neuronal cells found in the light-sensing retina layer at the back of the eye. The peptides might someday be used to treat degenerative retinal diseases, such as age-related macular degeneration (AMD).
Spectacular images of a molecule that shuttles omega-3 fatty acids into the brain may open a doorway for delivering neurological therapeutics to the brain.
A research team at the University of Chicago is now exploring the properties of a material found in cells which allows cells to remember and respond to environmental pressure. In a paper published on May 14, 2021 in Soft Matter, they teased out secrets for how it works--and how it could someday form the basis for making useful materials.
A new therapy prompts immune defense cells to swallow misshapen proteins, amyloid beta plaques and tau tangles, whose buildup is known to kill nearby brain cells as part of Alzheimer's disease, a new study shows.
A discovery from researchers at the University of Illinois Chicago may lead to new treatments for individuals who suffer from alcohol use disorder and depression.