Alzheimer's disease (AD) is the most common cause of dementia in elderly populations. Changes in the expression of the amyloid precursor protein (APP)-cleaving enzymes directly affect the formation of amyloid beta (Aβ) plaques, a neuropathological hallmark of AD.BACE1 mRNA level in AD subjects was significantly higher than those of healthy controls, whereas ADAM10 level was significantly lower in the AD subjects.
Patients who died of IS the most common type of dementia was vascular dementia while those died from other causes were most often diagnosed with Alzheimer's dementia (AD). Patients who died from IS and were registered in Riksstroke had higher MMSE score compared to other groups. Patients who died from IS took more cardiovascular medications. There were no differences in the use of antipsychotics, antidepressants, acetylcholinesterase inhibitors, memantine, anxiolytics, or hypnotics between the groups.
Nanomedicine is a field of science that employs materials in the nanometer scale.Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common disorders worldwide, becoming a serious economic burden and public health problem.In this review, we have highlighted the potential of lipid nanoparticles in reaching the brain, a challenging task in modern medicine.
Many species of mammals have evolved what appear to be paradoxical behaviors towards their young. Like humans, most exhibit nurturing, protective behaviors, and in some circumstances even act as surrogate parents. However, virgin males often engage in infanticide as a strategy to propagate their own genes. How are these conflicting social behaviors controlled?
The most comprehensive genomic analysis of the human brain ever undertaken has revealed new insights into the changes it undergoes through development, how it varies among individuals, and the roots of neuropsychiatric illnesses such as autism spectrum disorders and schizophrenia.
Louis Populin and collaborators at the University of Wisconsin-Madison collaborators published a study this week in the Journal of Neuroscience describing increased connections between key parts of the brains of monkeys who have taken methylphenidate (Ritalin).
Dr. Kazunobu Sawamoto (Professor, Nagoya City University and NIPS) and Dr. Naoko Kaneko (Associate professor, Nagoya City University) in collaboration with Dr. Atsushi Nambu (Professor, NIPS) and Dr. Yasuo Kawaguchi (Professor, NIPS) have revealed a novel mechanism for neuronal regeneration, using the mouse model for ischemic stroke.
A Mainz-based research team studied how glial cells develop in the brain from neural precursor cells. They discovered that differentiation involves three stages and that three proteins in the cell nucleus, so-called transcription factors, play a key role in organizing glia-specific transcription of the genes in the cell nucleus.
Researchers have discovered what might be an effective strategy to prevent and combat cognitive dysfunction in obese individuals. They are the first to examine the modulatory role of an exercise-induced protein in the brain that promotes neuron survival and used high-intensity interval exercise (HIIE) in obese and normal-weight subjects. Obesity reduces the expression of this protein and lower levels are associated with Alzheimer's, Parkinson's and obesity. HIIE upregulated this protein in the obese subjects compared to normal-weight subjects.
Animals are much better at smelling a complex 'soup' of odorants rather than a single pure ingredient, a new study by the University of Sussex has revealed.