Scientists studying plant biochemistry at the US Department of Energy's Brookhaven National Laboratory recently made a surprising discovery: They found that a protein that turns on oil synthesis also activates a protein that puts the brakes on the same process. In a paper just published in the journal Plant Physiology, they describe how this seemingly paradoxical system keeps oil precursors perfectly balanced to meet plants' needs.
Modesto Orozco's lab (IRB Barcelona) has published a study on the reaction mechanism of DNAzymes in Nature Catalysis. DNAzymes, which are catalysers formed by DNA, have applications in biomedicine and biotechnology. These research results will contribute to advances in the design and improvement of catalysers for therapeutic purposes.
A team of researchers from McMaster University has mapped at atomic resolution a toxic protein linked to Alzheimer's disease, allowing them to better understand what is happening deep within the brain during the earliest stages of the disease.
For the first time, Bernese researchers have been able to solve the structure of a transport protein and thus to describe the functional mechanism that plays a significant role in the survival of cancer cells. This is an important step towards developing effective inhibitors and fight tumor growth.
Rather than relying on optics, the microscopy system offers a chemically encoded way to map biomolecules' relative positions.
When plants absorb excess light energy during photosynthesis, reactive oxygen species are produced, potentially causing oxidative stress that damages important structures. Plants can suppress the production of reactive oxygen species by oxidizing P700 (the reaction center chlorophyll in photosystem I). A new study has revealed more about this vital process.
A reconfigurable 'body-on-a-chip' model could transform drug development by simultaneously measuring compound efficacy and toxicity, for both target cells and other organs, such as the heart and liver, for both parent drugs and its metabolites. The findings demonstrate the same results determined from testing patients in clinical studies, without the need of animal studies, demonstrating the ability of a body-on-a-chip model to truly revolutionize biomedical research and personalized medicine.
Knowing how emissions are created can help reduce them.
Combining research-oriented teaching and interdisciplinary collaboration pays off: researchers at the University of Konstanz develop a novel spectroscopic approach to investigate hitherto difficult-to-observe protein structures. On 'campus.kn,' the online magazine of the University of Konstanz, we report on the new approach and its origin at the interface between chemistry and biology.
A new study on the behavior of water in cancer cells shows how methods usually limited to physics can be of great use in cancer research. The researchers, Murillo Longo Martins and Heloisa N. Bordallo at the Niels Bohr Institute, University of Copenhagen, have shown how a combination of neutron scattering and thermal analysis can be used to map the properties of water in breast cancer cells.