A University of Houston College of Medicine researcher has found how a protein inside the body reduces the adverse effects of hypertonicity, an imbalance of water and solutes inside cells, which leads to cell death.
Biomedical engineers at Duke University have demonstrated a method for controlling the phase separation of an emerging class of proteins to create artificial membrane-less organelles within human cells. The advance, similar to controlling how vinegar forms droplets within oil, creates opportunities for engineering synthetic structures to modulate existing cell functions or create entirely new behaviors within cells.
A lack of the mineral selenium in the diet puts people at risk of paracetamol overdose, even when the painkiller is taken at levels claimed to be safe on the packaging, according to collaborative research emerging from the University of Bath and Southwest University in China.
As the COVID-19 pandemic continues to spread, scientists and health care providers are seeking ways to keep the coronavirus from infecting tissues once they're exposed. A new study suggests luring the virus with a decoy -- an engineered, free-floating receptor protein - binds the virus and blocks infection.
In a study led by EPFL, scientists have developed a synthetic blood-thinner that, unlike all others, doesn't cause bleeding side-effects. The highly potent, highly selective, and highly stable molecule can suppress thrombosis while letting blood clot normally following injury.
Targeted protein degradation (TPD) represents a novel paradigm in drug discovery that could lead to more efficient medicines to treat diseases such as cancer. "Molecular glue degrader" are an emerging but understudied class of small molecules that have been shown to induce degradation of proteins commonly considered "undruggable". CeMM Researchers have described a strategy that, for the first time, enables the rational and highly scalable discovery of novel molecular glue degraders.
Researchers at Kanazawa University report in ACS Nano a high-speed atomic-force microscopy study of the formation of protein fibrils (amyloids) associated with pathologies in collaborated research with Showa University. Mixing different variants of a single protein and changing the acidity of its environment is shown to result in significant variations in amyloid structure and elongation rates.
A team of researchers from Japan has demonstrated a light-based reaction that yields high numbers of the base chemical component required to produce bioactive compounds used in common industry products. They published their results on June 11, 2020 in Organic Letters.
A small device, called "Smart Stirrer", performed a function of a conventional laboratory stir bar, has an integrated microprocessor and various sensors capable of wireless and autonomous report the conversion of properties of a solution. Results are sent to a computer over Bluetooth, and any changes notify the user wirelessly.
A novel mathematical modeling method has been developed to estimate operation models of biomolecular motors from single-molecule imaging data of motion with the Bayesian inference framework. The operation mechanism of a linear molecular motor "chitinase", which moves one-way on a chitin chain with degrading the chain passed by, was elucidated by mathematical modeling of experimental imaging data with the method.