Extracellular vesicles (EV) represent a promising vector system for biomolecules and drug delivery due to their natural origin and participation in intercellular communication. As the quantity of EVs is limited, it was proposed to induce the release of membrane vesicles from the surface of human cells by treatment with cytochalasin B. Cytochalasin B-induced membrane vesicles (CIMVs) were successfully tested as a vector for delivery of dye, nanoparticles, and a chemotherapeutic.
Antibiotic-resistant bacteria are a global and growing problem in health care. To be able to prevent further development of resistance developing, it is important to understand where and how antibiotic resistance in bacteria arises. New research from Uppsala University shows that low concentrations of antibiotics, too, can cause high antibiotic resistance to develop in bacteria.
Parvalbumin, a protein found in great quantities in several different fish species, has been shown to help prevent the formation of certain protein structures closely associated with Parkinson's disease. A new study from Chalmers University of Technology, Sweden, shines more light on the link between consumption of fish and better long-term neurological health.
In a world first, Australian researchers have identified a new DNA structure -- called the i-motif -- inside cells. A twisted 'knot' of DNA, the i-motif has never before been directly seen inside living cells. The new findings, from the Garvan Institute of Medical Research, are published today in the leading journal Nature Chemistry.
A team of Russian scientists together with foreign colleagues found out that the venom of crab spider Heriaeus melloteei may be used as a basis for developing treatment against hypokalemic periodic paralysis.
Findings from a new study conducted in rats reveal that females may be more susceptible to migraines and less responsive to treatment because of the way fluctuations in the hormone estrogen affect cells in the brain.
Accounting for cell components in saliva increases the reliability of biochemical tests for experience-driven epigenetic changes.
Need stronger timber, better biofuels or new sources of green chemicals? A systems biology model developed over decades of research led by NC State University will accelerate progress in engineering trees for specific needs.
Researchers of Peter the Great St. Petersburg Polytechnic University (SPbPU) within the framework of the Project 5-100 developed a unique method of immune diseases diagnosing before the symptoms appear. Scientists proposed a laser-correlation spectroscopic technique (also called dynamic light scattering) for studying the immune response in body fluids, for example, in saliva.
A multidisciplinary team of scientists share recent advancements in innovative in-vitro cancer biology methods for screening drug-like molecules in cancer tissue relevant models in a new report published online ahead-of-print at SLAS Discovery. Entitled Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening, the report can be accessed for free.