New research published in the Feb. 23 issue of the Journal of Biological Chemistry identifies an enzyme that turns off transglutaminase 2, potentially paving the way for new treatments for celiac disease.
Brazilian scientists compare primitive Earth scenario with satellite Europa's conditions; the jupiterian moon could host microorganisms at the bottom of a huge warm ocean located underneath its frozen crust.
Cetuximab (CET) is a monoclonal antibody that inhibits epidermal growth factor receptor (EGFR) used for immunotherapy of different types of cancer. This study describes the development and full validation of a new enzyme-linked immunosorbent assay (ELISA) with high sensitivity and selectivity for bioanalysis of CET.
Using nitrogen fertilizer increases crop yields, but excess runoff causes environmental pollution. Moreover, in grains such as rice, large amounts of nitrogen fertilizer can delay flowering, leaving the crop vulnerable to late-season cold weather. A recent study in The Plant Cell identified a rice nitrate transporter that can be overexpressed to increase grain yield and accelerate flowering. This approach has the potential to improve grain yields while avoiding the downside of late maturation.
A research team at the University of California, Riverside has discovered a way for chemotherapy drug paclitaxel to target migrating, or circulating, cancer cells, which are responsible for the development of tumor metastases. Until now, paclitaxel has only been used to target rapidly dividing cancer cells. The team was successful in getting the drug to piggyback on 123B9, an agent they devised to target an oncogene called EphA2.
Using an innovative crystallization technique for studying 3D structures of gene transcription machinery, researchers revealed new insights into the long debated action of the 'magic spot' -- a molecule that controls gene expression in E. coli and many other bacteria when the bacteria are stressed. The study contributes to fundamental understanding of how bacteria adapt and survive under adverse conditions and provides clues about key processes that could be targeted in the search for new antibiotics.
Researchers at The University of Texas at Dallas have devised a new technique to isolate aggressive cells thought to form the root of many hard-to-treat metastasized cancers -- a significant step toward developing new drugs that might target these cells.
Determining the three dimensional structure of the protein could help to develop new treatments of Huntington's disease.
A team from the University of Liège has discovered a new crosstalk between the migrating inhibitory interneurons and the stem cells that generate the excitatory neurons. The researchers discovered that this cellular dialogue controls the growth of the cerebral cortex and that its impairment leads a cortical malformation previously associated with autism in mice. Their results are published in the prestigious scientific journal Cell.
Nanomedicine entry into cancer cells can be tuned by modulating the stiffness of the plasma membrane.