University of Groningen scientists have developed nanopores that can be used to directly measure the mass of peptides. Although the resolution needs to be improved, this proof of principle shows that a cheap and portable peptide mass spectrometer can be constructed using existing nanopore technology and the patented pores that were developed in the lab of UG Associate Professor of Chemical Biology, Giovanni Maglia. This discovery was published in Nature Communications on 19 February.
Researchers at Cardiff University have used X-ray crystallography and computer simulation to get a closer look at how viruses bind cells and cause infection.
A new study, published in The Journal of Clinical Investigation, establishes that the stress hormone epinephrine sets off a cascade of biochemical reactions that favor breast cancer growth and spread in chronically stressed patients.
The creation of membranes is of enormous importance in biology, but also in many chemical applications developed by humans. These membranes are shaped spontaneously when soap-like molecules in water join together. Researchers at Eindhoven University of Technology now have a clear picture of the entire process. The results are published in Nature Chemistry.
Researchers from the Max Planck Institute for Evolutionary Anthropology in Germany describe two late Neandertals with exceptionally high nitrogen isotope ratios, which would traditionally be interpreted as the signature of freshwater fish consumption. By studying the isotope ratios of single amino acids, they however demonstrated that instead of fish, the adult Neandertal had a diet relying on large herbivore mammals and that the other Neandertal was a breastfeeding baby whose mother was also a carnivore.
Tuberculosis (TB) is one of the top ten causes of death worldwide. The genome of the bacterium that causes TB holds a special toxin-antitoxin system with spectacular action: once the toxin is activated, all bacterial cells die, stopping the disease. An international research team co-led by the Wilmanns group at EMBL in Hamburg investigated this promising feature for therapeutic targets. They now share the first high-resolution details of the system in Molecular Cell.
Children living in homes with all vinyl flooring or flame-retardant chemicals in the sofa have significantly higher concentrations of potentially harmful semi-volatile organic compounds (SVOCs) in their blood or urine than children from homes where these materials are not present, according to new Duke University-led research. The researchers presented their findings Feb. 17 at the annual meeting of the American Association for the Advancement of Science in Washington, D.C.
Recent advances to address hunger through agricultural discovery will be highlighted at this year's annual meeting of the AAAS. Session speaker and University of Illinois professor Donald Ort will discuss the global food security challenge and a recent breakthrough in Science that boosted crop growth by 40 percent by creating a shortcut for a glitch that plagues most food crops.
Researchers at the Medical University of South Carolina discovered a new mechanism for a class of anti-cancer drugs known as E1 inhibitors. Their findings, published in Nature Communications on Dec. 4, 2018, reveal a novel binding site that will promote drug design of more efficient E1 inhibitors.
Researchers from Trinity College Dublin have become the first to describe a model of mitochondrial epilepsy which raises hope for better therapies for patients with this incapacitating condition.Despite the severity of this epilepsy, up to now there have been no animal models available to provide a mechanistic understanding of the condition. That is set to change though as researchers at Trinity can now explain the important role that astrocytes play in seizure generation.