Scientists seeking to unlock secrets of cellular aging have identified a gene that triggers senescence, a phenomenon in which cells stop dividing. The gene, called CD36, is unusually active in older, senescent cells. Heightening CD36 activity also caused young, healthy cells to stop dividing, with the effect also spreading to nearby cells in the same petri dish.
The bottleneck of cationic antimicrobial peptides as anticancer therapeutics is their limited ability to penetrate cell membranes. Tokyo Medical and Dental University (TMDU) researchers discovered a cyclic decapeptide (termed peptide 1) that serves as a promising lead compound as a new intracellular delivery vehicle for therapeutically effective peptides. When conjugated with another membrane impermeable proapoptotic domain (PAD) peptide, the compound was found to have significantly inhibitory activity in cancer cell lines.
Our ability to exercise self-control is linked to our neurobiology.
When cells grow and divide to ensure a biological function, DNA must be unwound from its typical tightly packed form and copied into RNA to create proteins. When this process goes awry, the result could be diseases such as cancers. University of North Carolina School of Medicine researchers have discovered that a protein called Spt6 facilitates RNA degradation so that cells have just the right amount of RNA for the creation of proteins.
African weakly electric fish, commonly called baby whales, use incredibly brief electrical pulses to sense the world around them and communicate with other members of their species. Part of that electrical mechanism exists in humans -- and by studying these fish, scientists may unlock clues about conditions like epilepsy.
A first-of-its kind study, next generation sequencing is brought to bear to investigate a culprit in the path to Alzheimer's disease: the presence of viruses in the brain.
A new SLAS Discovery review article summarizes new methods of fragment-based lead discovery (FBLD) to identify new compounds as potential antibiotics. It explains how FBLD works and illustrates its advantages over conventional high-throughput screening.
The lungs can be a difficult organ to biopsy with a needle, so identifying lung cancer through a blood-based biopsy has lung cancer experts and patients optimistic. Knowing how and when to use a liquid biopsy is critically important and led global experts at the International Association for the Study of Lung Cancer (IASLC) to issue 'The IASLC Statement Paper: Liquid Biopsy for Advanced Non-Small Cell Lung Cancer (NSCLC),' available in the Journal of Thoracic Oncology.
Researchers have found that a previously uncharacterized tumor-suppressor protein plays an important role in the functioning of the immune system. The study, which will be published in the June 22 issue of the Journal of Biological Chemistry, unites studies of immunology and cancer biology.
Carnegie Mellon University's Biomedical Engineering and Chemical Engineering Professors Bob Tilton and Todd Przybycien recently co-authored a paper with Ph.D. students Brittany Nordmark and Toni Bechtel, and alumnus John Riley, further refining a process that could soon help provide clean water to many in water-scarce regions. The process, created by Tilton's former student and co-author Stephanie Velegol, uses sand and plant materials readily available in many developing nations.