Researchers from the University of Oxford's Department of Zoology have demonstrated pre-clinical success for a universal flu vaccine in a new paper published in Nature Communications.
Preliminary results from a phase I clinical trial have demonstrated the safety and tolerability of a cell therapy involving the ex vivo expansion of T cells and their subsequent infusion into HIV-infected individuals previously treated with antiretroviral therapy (ART). The study appears Sept. 21 in the journal Molecular Therapy.
In 2014, a dengue outbreak unexpectedly occurred in Tokyo. What does that mean for the 2020 summer Olympics and Paralympics being held in the city? Researchers report this week in PLOS Neglected Tropical Diseases that new controls and frameworks are recommended to detect dengue and other infectious diseases and help prevent their spread during the summer games.
A group of scientists from UNSW Sydney, the University of Sydney, Deakin University, Portugal and Brazil have unlocked the DNA of the cane toad, a poisonous amphibian that is a threat to many native Australian species. The findings were published in academic journal GigaScience today.
Beak and feather disease virus (BFDV) in wild parrot populations has been detected in eight new countries, raising concerns for threatened species. This highlights the need for greater awareness of the risks of the spread of infectious disease associated with the international trade in live parrots.
An international team of researchers has successfully deployed a Zika virus vaccine to target and kill human glioblastoma brain cancer stem cells, which had been transplanted into mice. In a study published this week in mBio®, the team shows that a live, attenuated version of the Zika virus could form the basis of a new treatment option for this fatal brain cancer.
Human herpesviruses such as HHV-6 can remain dormant in cells for many years without being noticed. When reactivated, they can cause serious clinical conditions. Researchers from Würzburg have now found a way of differentiating between active and inactive viruses.
A type of immune cell that produces a protein called CD4 plays an important role in protecting mice infected with the Zika virus against severe neurological disease, according to a study published Sept. 6 in the open-access journal PLOS Pathogens by Amelia Kahler Pinto of Saint Louis University, and colleagues. Based on the findings, vaccines that induce strong responses from these immune cells, known as CD4+T cells, should be developed to prevent invasion of the Zika virus into the brain and spinal cord.
New insights into how Kaposi's sarcoma-associated herpesvirus (KSHV) induces genome instability and promotes cell proliferation could lead to the development of novel antiviral therapies for KSHV-associated cancers, according to a study published Sept. 13 in the open-access journal PLOS Pathogens by Erle Robertson of the University of Pennsylvania, and colleagues.
Two new studies by scientists at Scripps Research are bringing Ebola virus's weaknesses into the spotlight, showing for the first time exactly how human and mouse antibodies can bind to the virus and stop infection--not only for Ebola virus, but for other closely related pathogens as well.